A new role for cohesin in regulating alternative splicing has been identified, providing insights into splicing mutations in human disease. Cohesin is known to play a key part in transcription, and ...

Cohesin is a ring-shaped protein that surrounds and moves around the DNA molecule, forming the loops. It is a crucial process for the cell. Understanding how cohesin works has been one of the ...

In recent years, it has become evident that the spatial organisation of the genome is key for its function. This depends on a number of factors, including the cohesin protein complex. This essential ...

The role of cohesin, its regulation, as well as its recently identified function as a potential driver or facilitator for tumors has been explained and revised by an international expert in cohesin.

Cohesin contributes to intrachromosomal loops that regulate metazoan gene expression by constraining interactions between promoter and enhancer elements. These structures can be subject to regulation ...

A cohesin molecule ensures the proper distribution of DNA during cell division. Scientists can now demonstrate the concept of its carabiner-like function by visualizing for the first time the open ...

Ana Losada, from the Spanish National Cancer Research Centre (CNIO), is the scientist who identified cohesin in vertebrates, a protein that is essential in cell division. Losada has studied cohesin ...

Thought LeadersMaxim Molodtsov, Ph.D. Randhir Kumar, Ph.D. From optical trapping experiments to insights into molecular force generation, Dr. Maxim Molodtsov shared how his research is uncovering the ...

Scientists at Nagoya University, with colleagues at Kyoto University in Japan, have uncovered a mechanism that allows a protein complex to bind to DNA without impeding some of the important processes ...

Premature ovarian failure is a major cause of female infertility. The genetic causes of this disorder remain unknown in most patients. Using whole-exome sequence analysis of a large consanguineous ...

In recent years it has become evident that the spatial organisation of the genome is key for its function. This organisation depends on a number of factors, the cohesin protein complex being one of ...