All cells within the same cancer are not the same. They all have genetic errors that turn them into tumor cells, but these errors are not identical. In each cancer, there are populations of cells with ...
From protein translation to mitosis, fundamental cellular processes are multifaceted and dynamic. Researchers seeking to understand the inner workings of a cell benefit from multidisciplinary ...
Compound efficacy, specificity, accuracy, and in vivo relevance are key drivers in the decision-making process for progressing drug candidates through the lead-optimization phase into clinical trials.
Cellular immunogenicity and immunotoxicity assays help scientists design, validate, and translate therapeutic research into treatments that weaponize the immune response against cancer.
Cell-based assays are used to study genes, proteins, and whole cellular functions, as well as the mechanisms that control them, by measuring specific cellular parameters. They have become an important ...
The disposition of antibody-based therapeutics is generally determined by both target-mediated and non-target processes, the latter being an often-overlooked aspect. Target-independent liabilities can ...
Evaluation of interferon-alfa 2b in a model of acute respiratory distress syndrome and pulmonary fibrosis induced by intratraqueal bleomycin in Wistar rats This is an ASCO Meeting Abstract from the ...
The early identification of antibody candidates with desired affinities and dissociation kinetics, binding epitopes and critical quality attributes is vital for avoiding later-phase failures caused by ...
High-throughput screening (HTS) is a cornerstone of modern drug discovery, enabling the evaluation of thousands to millions of potential drug compounds. Advances in automation and miniaturization have ...
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