All current local anesthetics block sensory signals—pain—but they also interrupt motor signals, which can be problematic. For example, too much epidural anesthesia can prevent mothers in labor from ...

Inspired by the natural bonding between a class of potent local anesthetics called site-1 sodium channel blockers (S1SCBs) and peptide sequences on the sodium channel in the nerve cell membrane, ...

Site 1 sodium channel blockers such as tetrodotoxin and saxitoxin are small-molecule drugs with powerful local anesthetic properties. They provide pain relief without toxic effects on local nerves and ...

The localized loss of sensation with resultant reduction in pain stimuli is the end result of local anesthesia. This mode of anesthesia is considered to be safer than general anesthesia, because it ...

There is a real need in the treatment of postoperative pain and in the management of problems of intractable pain for local anesthetics with a duration of action longer than six to eight hours, the ...

Pulp cells are essential for tooth development, and dentin repair and regeneration. In addition these cells have been identified as an important stem cell source. Local anesthetics are widely used in ...

Lidocaine and similar local anesthetics are effective for treating pain that emanates from damaged nerves, according to a systematic review of current evidence. Lidocaine and similar local anesthetics ...

A liposomal formulation of a local anesthetic shows promise for long-lasting pain relief with minimal toxicity, reports a research group led by Daniel S. Kohane of Harvard Medical School (Proc. Natl.

This medication is a local anesthetic, used in ophthalmology to determine fluid pressure inside the eye and for fitting of contact lenses. This medication is a local anesthetic used to treat painful ...