RMD Open

Dance as a double-edged sword: physiological adaptations, injury risks and therapeutic potential

Dance is a complex physical activity with high biomechanical and artistic demands that cause repetitive stress on the ...
RMD Open

Rare variants in genes related to inborn errors of immunity in patients with rheumatoid arthritis and secondary immunodeficiency

Objectives Treatment of rheumatoid arthritis (RA) relies on immunomodulatory drugs that can compromise immunity, inducing secondary immunodeficiency (SID). However, features of SID, such as ...
RMD Open

Emerging treatments for Sjögren’s disease: promising drugs on the horizon

Sjögren’s disease (SjD) is a chronic, multisystem autoimmune disorder characterised by lymphocytic infiltration of exocrine ...
RMD Open

Prevalence of sarcopenia in patients with rheumatoid arthritis: a cross-sectional study

Objective Sarcopenia, defined by reductions in muscle mass and strength, increases the risk of adverse outcomes in patients with rheumatoid arthritis (RA)—driven in part by chronic inflammation—and is ...
RMD Open

Therapist effects in real-world rehabilitation outcomes: a cohort study of the nationwide GLA:D osteoarthritis management programme in Denmark

Objective Unlike several other fields of healthcare, little is known about the size of ‘therapist effects’ on patient ...
RMD Open

Site-specific articular responses to b/tsDMARDs in rheumatoid arthritis: a longitudinal observational study from the Swiss Clinical Quality Management Registry

This joint-specific response pattern was consistent across all advanced treatment modalities, including abatacept, interleukin-6 receptor inhibitors, Janus kinase inhibitors, rituximab and TNFi.
RMD Open

Arrhythmic risk stratification in psoriatic arthritis: a retrospective, electrogram-based comparative analysis

Background Psoriatic arthritis (PsA) is a chronic inflammatory systemic disease that is associated with cardiovascular ...
rmdopen.bmj

Targeted proteomics identifies differentially expressed proteins in Sjögren’s disease with incident lymphoma

Objectives Patients with primary Sjögren’s disease (SjD) have an increased risk of B cell lymphoma. The aim of this study was to determine serum protein biomarkers for lymphoma development and to ...
rmdopen.bmj

Rheumatoid factor and anticitrullinated protein antibody status jointly influence the association between disease activity and cardiovascular risk in rheumatoid arthritis

Objectives Rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA) are linked to disease activity, severity and cardiovascular risk in rheumatoid arthritis (RA). Since RA-related ...
rmdopen.bmj

Metabolomic profiling of patients with lupus nephritis reveals unique metabolites that are modulated through type I interferon inhibition by anifrolumab treatment in a phase 2 ...

6 Translational Science and Experimental Medicine, Early Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK 7 Translational Science and Experimental Medicine, Early ...
rmdopen.bmj

MRI of shoulder girdle in polymyalgia rheumatica: inflammatory findings and their diagnostic value

Background Non-synovial inflammation as detected by MRI is characteristic in polymyalgia rheumatica (PMR) with potentially high diagnostic value. Objective The objective is to describe inflammatory ...
rmdopen.bmj

Serum calprotectin and complement factor C3 are superior biomarkers of inflammation in early psoriatic arthritis as compared with C-reactive protein

Objectives C reactive protein (CRP) is frequently normal in psoriatic arthritis (PsA) despite active disease, complicating inflammation assessment. This study aimed to evaluate alternative biomarkers ...