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Apr. 23, 2025 An international team has identified a potential microbial culprit behind the alarming rise in early-onset colorectal cancer: a bacterial toxin called colibactin. Scientists report that ...

Up to one-third of patients develop a cancer recurrence following surgery for colorectal cancer. Here, the authors show that a virulent gut microbial signature present on the day of surgery associates ...

Tumors driven by oncogenic KRAS toggle between MAPK-driven regenerative states and WNT-dependent stem-like states. Both signaling pathways must be blocked for sustained tumor control.