Could measuring proteins in the blood help pinpoint which genes underlie certain GWAS signals? By combining plasma proteomics data with genetic analyses, scientists led by Keenan Walker at the ...
Two new ApoE variants turned up in American populations. Protective variant W276C discourages ApoE from oligomerizing. Risk variant R189C promotes its lipidation. Lipidated ApoE4 disrupts microglial ...
As the outer surface of all animal cells, the plasma membrane is the foundation of cellular life. It also withstands a relentless onslaught of physical and chemical insults, which must be repaired on ...
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