Could measuring proteins in the blood help pinpoint which genes underlie certain GWAS signals? By combining plasma proteomics data with genetic analyses, scientists led by Keenan Walker at the ...

Two new ApoE variants turned up in American populations. Protective variant W276C discourages ApoE from oligomerizing. Risk variant R189C promotes its lipidation. Lipidated ApoE4 disrupts microglial ...

As the outer surface of all animal cells, the plasma membrane is the foundation of cellular life. It also withstands a relentless onslaught of physical and chemical insults, which must be repaired on ...

Comments Plasma Proteome Offers Clues to Risk and Resilience in APOE4 Carriers 26 Jun 2026 ...

Kenneth Chen, M.D., Ph.D. Stanford University School of Medicine Contact Information Kenneth Chen, M.D., Ph.D. United States ...

A blood test may be almost as good as a brain scan for determining where someone lies along the Alzheimer’s disease continuum. So conclude scientists led by Gemma Salvadó and Oskar Hansson at Lund ...

Biogen and Denali yesterday announced they will stop development of the LRRK2 kinase inhibitor DNL151 for sporadic Parkinson’s disease. Top-line data from the LUMA Phase 2b trial indicated that the ...

Can brain amyloid reduction be used as a surrogate biomarker of clinical benefit? This is a hotly debated question in the field (see Dec 2024 discussion). A recent post hoc analysis of Phase 3 ...

The world did not end today as predicted, but unfortunately we have to report that development of another potential drug did. Allon Therapeutics Inc. announced 19 December that its drug candidate ...

Scientists already suspect that somatic mutations—those that accrue in cells outside the germline over a person’s lifetime, seemingly at random—play a role in neurodegenerative diseases. Now, several ...

CAR-T cell therapy has practically become a household name, given its success in taking down blood cancers. The chimeric antigen receptors used in this type of cell therapy are designed to sic killer ...

These transgenic mice overexpress mutant human LRRK2 throughout the brain via a promoter that drives neuronal-specific expression (Ramonet et al., 2011). Nonetheless, the mutant human protein is also ...