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Abstract. Glucocorticoid receptor (GR) signaling is critical to our physiology but is dysregulated in cancer by the pain, psychologic distress, iatrogenic morbidity, and pathology associated with an ...

Cancer Research

HER2 Heterogeneous Breast Cancer Models Reveal Novel Therapeutic Targets and Subclonal Dynamics during Evolution to Resistance to HER2-Targeted Therapies

2Department of Medicine, Harvard Medical School, Boston, Massachusetts. 3Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts.

Cancer Research

GDF15 Reprograms the Microenvironment to Drive Liver Metastasis of Uveal Melanoma

AbstractUveal melanoma is an aggressive tumor type that frequently results in fatal liver metastasis. A better understanding of the interactions between uveal melanoma and host cells in the tumor ...

Cancer Research

Christine A. Iacobuzio-Donahue

Ming Li Han Liang Jonathan Licht De-Chen Lin Hui-Kuan Lin Piro Lito David Lyden Conor C. Lynch Mathieu Lupien Li Ma Anant Madabhushi Andriy Marusyk Massimiliano Mazzone John D. Minna Lindsay M. Morton ...

Cancer Research

PROTEUS May Mean New SOC for Some Prostate Cancers

Abstract:. For people with localized, high-risk prostate cancer, treatment with 6 months of apalutamide and androgen deprivation therapy (ADT) both before and after surgery reduces the risk of ...

Cancer Research

In Vivo CAR T-Cell Therapy Spurs 100% ORR in Phase I

Abstract:. In the phase I inMMyCAR study of the in vivo chimeric antigen receptor (CAR) T-cell therapy KLN-1010, all 18 patients with multiple myeloma responded. None of the evaluable patients had ...

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