A method for arrayed CRISPRi screening in organoids enables the investigation of morphogenesis in human stem cell-derived tissues, revealing the roles of ZIC2, SOX11, and ZNF521 in neural tube closure ...

Researchers have developed a new tool that can screen genes involved in human development at unprecedented scale and speed, using it in a proof-of-principle study to reveal new insights into human ...

Genes associated with male reproductive biology appear to be under relaxed selective constraint in a primate species with low sperm competition.

Analysis of data across many different studies shows that children's word recognition improves continuously from infancy through age 5 years, and shows strong coupling with early vocabulary.

A study suggests babies’ brains recognize music from as young as three months of age, while spontaneous movements to music emerge by their first birthday and their ability to match movements to it ...

Although auditory encoding of music is robust early in infancy, the transformation of this input into movement patterns develops substantially over the first postnatal year, without reaching full ...

A framework for analyzing single-cell genomics data, in which geometrical properties are harnessed to obtain insights on cellular diversity, including precise clustering, clear visualizations, and ...

Single neurons in mouse sensorimotor cortex are organized by their activity features into distinct subpopulations with area-spanning footprints whose boundaries align closely with anatomical and ...

eLife reviews research in areas including cell migration, proliferation and differentiation, and inductive and signaling interactions. Learn more about what we review and sign up for the latest ...

Specialized anatomical structures in the mouth and feet of tsetse flies help them feed on blood from a variety of hosts.

eLife reviews research in which approaches from the physical sciences are used to provide insights into the properties of biological systems and processes. Learn more about what we review and sign up ...

The subthalamic nucleus contains subpopulations with different contributions to deliberative decision-making based on noisy evidence and reward-driven preferences.