RMD Open

Anifrolumab, a potential treatment for ADA2 deficiency

Adenosine deaminase 2 deficiency (DADA2) is an inborn error of immunity leading to systemic vasculitis, haematological manifestations, immune deficiency and/or autoimmunity. We report the case of a 26 ...
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Current Issue

Original research: Association between SARS-CoV-2 booster vaccination and hospitalisation and/or death due to COVID-19 in adults with immune-mediated inflammatory diseases: nested case–control study ...
RMD Open

Prevalence of sarcopenia in patients with rheumatoid arthritis: a cross-sectional study

Objective Sarcopenia, defined by reductions in muscle mass and strength, increases the risk of adverse outcomes in patients with rheumatoid arthritis (RA)—driven in part by chronic inflammation—and is ...
RMD Open

Rare variants in genes related to inborn errors of immunity in patients with rheumatoid arthritis and secondary immunodeficiency

Objectives Treatment of rheumatoid arthritis (RA) relies on immunomodulatory drugs that can compromise immunity, inducing secondary immunodeficiency (SID). However, features of SID, such as ...
RMD Open

Dance as a double-edged sword: physiological adaptations, injury risks and therapeutic potential

Dance is a complex physical activity with high biomechanical and artistic demands that cause repetitive stress on the ...
RMD Open

Therapist effects in real-world rehabilitation outcomes: a cohort study of the nationwide GLA:D osteoarthritis management programme in Denmark

Objective Unlike several other fields of healthcare, little is known about the size of ‘therapist effects’ on patient ...
RMD Open

Emerging treatments for Sjögren’s disease: promising drugs on the horizon

Sjögren’s disease (SjD) is a chronic, multisystem autoimmune disorder characterised by lymphocytic infiltration of exocrine ...
RMD Open

Arrhythmic risk stratification in psoriatic arthritis: a retrospective, electrogram-based comparative analysis

Background Psoriatic arthritis (PsA) is a chronic inflammatory systemic disease that is associated with cardiovascular ...
RMD Open

Site-specific articular responses to b/tsDMARDs in rheumatoid arthritis: a longitudinal observational study from the Swiss Clinical Quality Management Registry

This joint-specific response pattern was consistent across all advanced treatment modalities, including abatacept, interleukin-6 receptor inhibitors, Janus kinase inhibitors, rituximab and TNFi.
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Rheumatoid factor and anticitrullinated protein antibody status jointly influence the association between disease activity and cardiovascular risk in rheumatoid arthritis

Objectives Rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA) are linked to disease activity, severity and cardiovascular risk in rheumatoid arthritis (RA). Since RA-related ...
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Metabolomic profiling of patients with lupus nephritis reveals unique metabolites that are modulated through type I interferon inhibition by anifrolumab treatment in a phase 2 ...

6 Translational Science and Experimental Medicine, Early Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK 7 Translational Science and Experimental Medicine, Early ...
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Elevated serum levels of interleukin-18 discriminate Still’s disease from other autoinflammatory conditions: results from the European ImmunAID cohort

Objectives Systemic autoinflammatory diseases (SAIDs) represent a set of conditions with exaggerated innate immune responses. IL-1β and IL-18 are key cytokines involved in the pathogenesis of some ...